Sodium in PDB 8ss7: Structure of Ampa Receptor GLUA2 Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk, Channel Blocker Spermidine and Antiepileptic Drug Perampanel (Closed State)

The structure of Structure of Ampa Receptor GLUA2 Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk, Channel Blocker Spermidine and Antiepileptic Drug Perampanel (Closed State) also contains other interesting chemical elements:

Fluorine

(F)

12 atoms

The binding sites of Sodium atom in the Structure of Ampa Receptor GLUA2 Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk, Channel Blocker Spermidine and Antiepileptic Drug Perampanel (Closed State) (pdb code 8ss7). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Structure of Ampa Receptor GLUA2 Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk, Channel Blocker Spermidine and Antiepileptic Drug Perampanel (Closed State), PDB code: 8ss7:

Sodium binding site 1 out of 1 in the Structure of Ampa Receptor GLUA2 Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk, Channel Blocker Spermidine and Antiepileptic Drug Perampanel (Closed State)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Structure of Ampa Receptor GLUA2 Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk, Channel Blocker Spermidine and Antiepileptic Drug Perampanel (Closed State) within 5.0Å range: probe atom residue distance (Å) B Occ A:Na1111 b:24.6 occ:1.00 OG1 C:THR625 3.3 24.8 1.0 OG1 A:THR625 3.3 21.4 1.0 OG1 D:THR625 3.7 34.5 1.0 OG1 B:THR625 3.8 31.4 1.0 O C:ALA621 3.9 16.5 1.0 O A:ALA621 4.0 13.5 1.0 CB A:THR625 4.2 21.4 1.0 CB C:THR625 4.2 24.8 1.0 O D:ALA621 4.2 24.7 1.0 O B:ALA621 4.3 21.6 1.0 CB D:ALA621 4.4 24.7 1.0 CB C:ALA621 4.4 16.5 1.0 CG2 A:THR625 4.4 21.4 1.0 CG2 C:THR625 4.4 24.8 1.0 CB A:ALA621 4.4 13.5 1.0 CB B:ALA621 4.5 21.6 1.0 C C:ALA621 4.5 16.5 1.0 C A:ALA621 4.5 13.5 1.0 C D:ALA621 4.6 24.7 1.0 CB D:THR625 4.6 34.5 1.0 CB B:THR625 4.7 31.4 1.0 C B:ALA621 4.7 21.6 1.0 CG2 D:THR625 4.7 34.5 1.0 CG2 B:THR625 4.7 31.4 1.0

S.P.Gangwar, L.Y.Yen, M.V.Yelshanskaya, A.I.Sobolevsky. Modulation of GLUA2-GAMMA5 Synaptic Complex Desensitization, Polyamine Block and Antiepileptic Perampanel Inhibition By Auxiliary Subunit Cornichon-2 Nat.Struct.Mol.Biol. 2023.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-023-01080-X