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Atomistry » Sodium » PDB 8fry-8g2e » 8fui | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Sodium » PDB 8fry-8g2e » 8fui » |
Sodium in PDB 8fui: Hiv-1 Wild Type Protease with Grl-02519A, with N-(2,5-Dimethylphenyl)- 4-(Pyridin-3-Yl)Pyrimidin-2-Amine As P2-P3 GroupEnzymatic activity of Hiv-1 Wild Type Protease with Grl-02519A, with N-(2,5-Dimethylphenyl)- 4-(Pyridin-3-Yl)Pyrimidin-2-Amine As P2-P3 Group
All present enzymatic activity of Hiv-1 Wild Type Protease with Grl-02519A, with N-(2,5-Dimethylphenyl)- 4-(Pyridin-3-Yl)Pyrimidin-2-Amine As P2-P3 Group:
3.4.23.16; Protein crystallography data
The structure of Hiv-1 Wild Type Protease with Grl-02519A, with N-(2,5-Dimethylphenyl)- 4-(Pyridin-3-Yl)Pyrimidin-2-Amine As P2-P3 Group, PDB code: 8fui
was solved by
Y.-F.Wang,
A.E.Wong-Sam,
A.K.Ghosh,
I.T.Weber,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 8fui:
The structure of Hiv-1 Wild Type Protease with Grl-02519A, with N-(2,5-Dimethylphenyl)- 4-(Pyridin-3-Yl)Pyrimidin-2-Amine As P2-P3 Group also contains other interesting chemical elements:
Sodium Binding Sites:
The binding sites of Sodium atom in the Hiv-1 Wild Type Protease with Grl-02519A, with N-(2,5-Dimethylphenyl)- 4-(Pyridin-3-Yl)Pyrimidin-2-Amine As P2-P3 Group
(pdb code 8fui). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Hiv-1 Wild Type Protease with Grl-02519A, with N-(2,5-Dimethylphenyl)- 4-(Pyridin-3-Yl)Pyrimidin-2-Amine As P2-P3 Group, PDB code: 8fui: Jump to Sodium binding site number: 1; 2; Sodium binding site 1 out of 2 in 8fuiGo back to Sodium Binding Sites List in 8fui
Sodium binding site 1 out
of 2 in the Hiv-1 Wild Type Protease with Grl-02519A, with N-(2,5-Dimethylphenyl)- 4-(Pyridin-3-Yl)Pyrimidin-2-Amine As P2-P3 Group
Mono view Stereo pair view
Sodium binding site 2 out of 2 in 8fuiGo back to Sodium Binding Sites List in 8fui
Sodium binding site 2 out
of 2 in the Hiv-1 Wild Type Protease with Grl-02519A, with N-(2,5-Dimethylphenyl)- 4-(Pyridin-3-Yl)Pyrimidin-2-Amine As P2-P3 Group
Mono view Stereo pair view
Reference:
A.K.Ghosh,
J.L.Mishevich,
S.Kovela,
R.Shaktah,
A.K.Ghosh,
M.Johnson,
Y.F.Wang,
A.Wong-Sam,
J.Agniswamy,
M.Amano,
Y.Takamatsu,
S.I.Hattori,
I.T.Weber,
H.Mitsuya.
Exploration of Imatinib and Nilotinib-Derived Templates As the P2-Ligand For Hiv-1 Protease Inhibitors: Design, Synthesis, Protein X-Ray Structural Studies, and Biological Evaluation. Eur.J.Med.Chem. V. 255 15385 2023.
Page generated: Wed Oct 9 11:58:11 2024
ISSN: ISSN 0223-5234 PubMed: 37150084 DOI: 10.1016/J.EJMECH.2023.115385 |
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