Sodium in PDB 8fht: Cryo-Em Structure of Human Ncc

The structure of Cryo-Em Structure of Human Ncc also contains other interesting chemical elements:

Chlorine

(Cl)

2 atoms

The binding sites of Sodium atom in the Cryo-Em Structure of Human Ncc (pdb code 8fht). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Cryo-Em Structure of Human Ncc, PDB code: 8fht:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Cryo-Em Structure of Human Ncc


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Cryo-Em Structure of Human Ncc within 5.0Å range: probe atom residue distance (Å) B Occ A:Na1101 b:31.8 occ:1.00 O A:TRP151 2.2 27.9 1.0 OG A:SER468 2.3 33.8 1.0 O A:LEU148 2.3 34.6 1.0 O A:ALA464 2.5 33.1 1.0 OG A:SER467 2.7 35.2 1.0 C A:ALA464 3.2 33.1 1.0 CA A:ALA464 3.3 33.1 1.0 N A:SER468 3.4 33.8 1.0 C A:TRP151 3.5 27.9 1.0 C A:LEU148 3.6 34.6 1.0 CB A:SER468 3.6 33.8 1.0 CB A:SER467 3.8 35.2 1.0 CB A:ALA464 3.8 33.1 1.0 CA A:SER468 3.9 33.8 1.0 CA A:GLY152 4.2 26.1 1.0 C A:SER467 4.2 35.2 1.0 N A:GLY152 4.3 26.1 1.0 CA A:LEU148 4.4 34.6 1.0 CA A:TRP151 4.5 27.9 1.0 N A:THR465 4.5 33.4 1.0 CA A:SER467 4.5 35.2 1.0 N A:ASN149 4.5 31.1 1.0 O A:GLY463 4.5 34.4 1.0 CA A:ASN149 4.5 31.1 1.0 O A:ASN149 4.6 31.1 1.0 CD2 A:LEU148 4.6 34.6 1.0 N A:ALA464 4.6 33.1 1.0 CB A:TRP151 4.7 27.9 1.0 C A:ASN149 4.7 31.1 1.0 N A:TRP151 4.7 27.9 1.0 N A:SER467 4.8 35.2 1.0 CB A:LEU148 4.9 34.6 1.0

Sodium binding site 2 out of 2 in the Cryo-Em Structure of Human Ncc


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Cryo-Em Structure of Human Ncc within 5.0Å range: probe atom residue distance (Å) B Occ B:Na1101 b:31.6 occ:1.00 O B:TRP151 2.2 28.1 1.0 OG B:SER468 2.3 33.9 1.0 O B:LEU148 2.4 34.4 1.0 O B:ALA464 2.4 33.2 1.0 OG B:SER467 2.7 35.4 1.0 C B:ALA464 3.2 33.2 1.0 CA B:ALA464 3.3 33.2 1.0 N B:SER468 3.4 33.9 1.0 C B:TRP151 3.5 28.1 1.0 CB B:SER468 3.6 33.9 1.0 C B:LEU148 3.6 34.4 1.0 CB B:ALA464 3.8 33.2 1.0 CB B:SER467 3.8 35.4 1.0 CA B:SER468 3.9 33.9 1.0 CA B:GLY152 4.2 26.0 1.0 C B:SER467 4.2 35.4 1.0 N B:GLY152 4.3 26.0 1.0 CA B:LEU148 4.4 34.4 1.0 N B:THR465 4.4 33.4 1.0 CA B:SER467 4.5 35.4 1.0 CA B:TRP151 4.5 28.1 1.0 O B:GLY463 4.5 34.8 1.0 N B:ASN149 4.5 31.3 1.0 O B:ASN149 4.6 31.3 1.0 CA B:ASN149 4.6 31.3 1.0 N B:ALA464 4.6 33.2 1.0 CD2 B:LEU148 4.6 34.4 1.0 CB B:TRP151 4.7 28.1 1.0 C B:ASN149 4.7 31.3 1.0 N B:TRP151 4.7 28.1 1.0 N B:SER467 4.7 35.4 1.0 CB B:LEU148 4.9 34.4 1.0

M.Fan, J.Zhang, C.Lee, J.Zhang, L.Feng. Structure and Thiazide Inhibition Mechanism of the Human Na-Cl Cotransporter Nature 2023.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-023-05718-0