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Sodium in PDB 8cx9: Structure of the Sars-COV2 Plpro (C111S) in Complex with A Dimeric Ubv That Inhibits Activity By An Unusual Allosteric Mechanism
Enzymatic activity of Structure of the Sars-COV2 Plpro (C111S) in Complex with A Dimeric Ubv That Inhibits Activity By An Unusual Allosteric Mechanism
All present enzymatic activity of Structure of the Sars-COV2 Plpro (C111S) in Complex with A Dimeric Ubv That Inhibits Activity By An Unusual Allosteric Mechanism:
3.4.19.12;
3.4.19.12;
Protein crystallography data
The structure of Structure of the Sars-COV2 Plpro (C111S) in Complex with A Dimeric Ubv That Inhibits Activity By An Unusual Allosteric Mechanism, PDB code: 8cx9
was solved by
A.U.Singer,
C.L.Slater,
A.Patel,
R.Russel,
B.L.Mark,
S.S.Sidhu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 47.79 / 3.50 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 54.58, 174.86, 121.56, 90, 95.74, 90 |
| R / Rfree (%) | 22.5 / 27 |
Other elements in 8cx9:
The structure of Structure of the Sars-COV2 Plpro (C111S) in Complex with A Dimeric Ubv That Inhibits Activity By An Unusual Allosteric Mechanism also contains other interesting chemical elements:
| Bromine | (Br) | 6 atoms |
| Chlorine | (Cl) | 1 atom |
| Zinc | (Zn) | 4 atoms |
Sodium Binding Sites:
The binding sites of Sodium atom in the Structure of the Sars-COV2 Plpro (C111S) in Complex with A Dimeric Ubv That Inhibits Activity By An Unusual Allosteric Mechanism
(pdb code 8cx9). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Structure of the Sars-COV2 Plpro (C111S) in Complex with A Dimeric Ubv That Inhibits Activity By An Unusual Allosteric Mechanism, PDB code: 8cx9:
Jump to Sodium binding site number: 1; 2;
In total 2 binding sites of Sodium where determined in the Structure of the Sars-COV2 Plpro (C111S) in Complex with A Dimeric Ubv That Inhibits Activity By An Unusual Allosteric Mechanism, PDB code: 8cx9:
Jump to Sodium binding site number: 1; 2;
Sodium binding site 1 out of 2 in 8cx9
Go back to
Sodium Binding Sites List in 8cx9
Sodium binding site 1 out
of 2 in the Structure of the Sars-COV2 Plpro (C111S) in Complex with A Dimeric Ubv That Inhibits Activity By An Unusual Allosteric Mechanism
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Sodium with other atoms in the Na binding
site number 1 of Structure of the Sars-COV2 Plpro (C111S) in Complex with A Dimeric Ubv That Inhibits Activity By An Unusual Allosteric Mechanism within 5.0Å range:
|
Sodium binding site 2 out of 2 in 8cx9
Go back to
Sodium Binding Sites List in 8cx9
Sodium binding site 2 out
of 2 in the Structure of the Sars-COV2 Plpro (C111S) in Complex with A Dimeric Ubv That Inhibits Activity By An Unusual Allosteric Mechanism
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Sodium with other atoms in the Na binding
site number 2 of Structure of the Sars-COV2 Plpro (C111S) in Complex with A Dimeric Ubv That Inhibits Activity By An Unusual Allosteric Mechanism within 5.0Å range:
|
Reference:
V.J.E.Van Vliet,
N.Huynh,
J.Pala,
A.Patel,
A.Singer,
C.Slater,
J.Chung,
M.Van Huizen,
J.Teyra,
S.Miersch,
G.K.Luu,
W.Ye,
N.Sharma,
S.S.Ganaie,
R.Russell,
C.Chen,
M.Maynard,
G.K.Amarasinghe,
B.L.Mark,
M.Kikkert,
S.S.Sidhu.
Ubiquitin Variants Potently Inhibit Sars-Cov-2 Plpro and Viral Replication Via A Novel Site Distal to the Protease Active Site. Plos Pathog. V. 18 11065 2022.
ISSN: ESSN 1553-7374
PubMed: 36548304
DOI: 10.1371/JOURNAL.PPAT.1011065
Page generated: Wed Oct 9 11:19:37 2024
ISSN: ESSN 1553-7374
PubMed: 36548304
DOI: 10.1371/JOURNAL.PPAT.1011065
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