Sodium in PDB 8c9g: Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin

Enzymatic activity of Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin

All present enzymatic activity of Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin:
6.1.1.5;

Protein crystallography data

The structure of Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin, PDB code: 8c9g was solved by A.Brkic, M.Leibundgut, J.Jablonska, V.Zanki, Z.Car, V.Petrovic Perokovic, N.Ban, I.Gruic-Sovulj, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 60.39 / 2.80
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 66.82, 144.28, 108.37, 90, 95.64, 90
R / Rfree (%) 20 / 25.8

Other elements in 8c9g:

The structure of Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin also contains other interesting chemical elements:

Chlorine (Cl) 4 atoms
Zinc (Zn) 2 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin (pdb code 8c9g). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 3 binding sites of Sodium where determined in the Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin, PDB code: 8c9g:
Jump to Sodium binding site number: 1; 2; 3;

Sodium binding site 1 out of 3 in 8c9g

Go back to Sodium Binding Sites List in 8c9g
Sodium binding site 1 out of 3 in the Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na1005

b:57.9
occ:1.00
 OE2 A:GLU331 3.6 93.9 1.0
CA A:GLY448 4.5 67.4 1.0
O A:ARG447 4.6 78.3 1.0
CD A:GLU331 4.8 85.5 1.0
N A:GLY448 4.9 75.2 1.0

Sodium binding site 2 out of 3 in 8c9g

Go back to Sodium Binding Sites List in 8c9g
Sodium binding site 2 out of 3 in the Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Na1007

b:53.5
occ:1.00
 SD B:MET803 4.0 90.5 1.0
CG B:MET803 4.0 84.0 1.0
CE B:MET803 4.1 74.7 1.0
CB B:MET803 4.2 78.4 1.0
CG2 B:ILE713 4.3 58.0 1.0
OD1 B:ASP807 4.6 101.8 1.0
OD1 B:ASP714 4.7 54.6 1.0
OD2 B:ASP807 5.0 89.9 1.0

Sodium binding site 3 out of 3 in 8c9g

Go back to Sodium Binding Sites List in 8c9g
Sodium binding site 3 out of 3 in the Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Na1008

b:49.7
occ:1.00
 O B:SER84 4.1 62.8 1.0
CE2 B:PHE86 4.1 66.8 1.0
CZ B:PHE86 4.1 74.0 1.0
O B:GLY85 4.4 69.3 1.0
CD2 B:PHE86 4.8 53.3 1.0
CE1 B:PHE86 4.8 63.2 1.0
C B:GLY85 4.8 61.1 1.0
CA B:GLY85 4.9 57.2 1.0

Reference:

A.Brkic, M.Leibundgut, J.Jablonska, V.Zanki, Z.Car, V.Petrovic Perokovic, N.Ban, I.Gruic-Sovulj. Antibiotic Hyper-Resistance in A Class I Aminoacyl-Trna Synthetase with Altered Active Site Signature Motif To Be Published.
Page generated: Wed Oct 9 10:53:13 2024

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