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Atomistry » Sodium » PDB 7zyq-8acy » 7zzr | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Sodium » PDB 7zyq-8acy » 7zzr » |
Sodium in PDB 7zzr: HDAC2 in Complex with Inhibitory LigandEnzymatic activity of HDAC2 in Complex with Inhibitory Ligand
All present enzymatic activity of HDAC2 in Complex with Inhibitory Ligand:
3.5.1.98; Protein crystallography data
The structure of HDAC2 in Complex with Inhibitory Ligand, PDB code: 7zzr
was solved by
A.Cleasby,
D.Tisi,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7zzr:
The structure of HDAC2 in Complex with Inhibitory Ligand also contains other interesting chemical elements:
Sodium Binding Sites:
The binding sites of Sodium atom in the HDAC2 in Complex with Inhibitory Ligand
(pdb code 7zzr). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total 3 binding sites of Sodium where determined in the HDAC2 in Complex with Inhibitory Ligand, PDB code: 7zzr: Jump to Sodium binding site number: 1; 2; 3; Sodium binding site 1 out of 3 in 7zzrGo back to Sodium Binding Sites List in 7zzr
Sodium binding site 1 out
of 3 in the HDAC2 in Complex with Inhibitory Ligand
Mono view Stereo pair view
Sodium binding site 2 out of 3 in 7zzrGo back to Sodium Binding Sites List in 7zzr
Sodium binding site 2 out
of 3 in the HDAC2 in Complex with Inhibitory Ligand
Mono view Stereo pair view
Sodium binding site 3 out of 3 in 7zzrGo back to Sodium Binding Sites List in 7zzr
Sodium binding site 3 out
of 3 in the HDAC2 in Complex with Inhibitory Ligand
Mono view Stereo pair view
Reference:
E.Tamanini,
S.Miyamura,
I.M.Buck,
B.D.Cons,
L.Dawson,
C.East,
T.Futamura,
S.Goto,
C.Griffiths-Jones,
T.Hashimoto,
T.D.Heightman,
S.Ishikawa,
H.Ito,
Y.Kaneko,
T.Kawato,
K.Kondo,
N.Kurihara,
J.M.Mccarthy,
Y.Mori,
T.Nagase,
Y.Nakaishi,
J.Reeks,
A.Sato,
P.Schopf,
K.Tai,
T.Tamai,
D.Tisi,
A.J.Woolford.
Fragment-Based Discovery of A Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett. V. 13 1591 2022.
Page generated: Wed Oct 9 10:21:41 2024
ISSN: ISSN 1948-5875 PubMed: 36262388 DOI: 10.1021/ACSMEDCHEMLETT.2C00272 |
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