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Atomistry » Sodium » PDB 7zyq-8acy » 7zzo | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Sodium » PDB 7zyq-8acy » 7zzo » |
Sodium in PDB 7zzo: HDAC2 in Complex with An InhibitorEnzymatic activity of HDAC2 in Complex with An Inhibitor
All present enzymatic activity of HDAC2 in Complex with An Inhibitor:
3.5.1.98; Protein crystallography data
The structure of HDAC2 in Complex with An Inhibitor, PDB code: 7zzo
was solved by
A.Cleasby,
D.Tisi,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7zzo:
The structure of HDAC2 in Complex with An Inhibitor also contains other interesting chemical elements:
Sodium Binding Sites:
The binding sites of Sodium atom in the HDAC2 in Complex with An Inhibitor
(pdb code 7zzo). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total 3 binding sites of Sodium where determined in the HDAC2 in Complex with An Inhibitor, PDB code: 7zzo: Jump to Sodium binding site number: 1; 2; 3; Sodium binding site 1 out of 3 in 7zzoGo back to Sodium Binding Sites List in 7zzo
Sodium binding site 1 out
of 3 in the HDAC2 in Complex with An Inhibitor
Mono view Stereo pair view
Sodium binding site 2 out of 3 in 7zzoGo back to Sodium Binding Sites List in 7zzo
Sodium binding site 2 out
of 3 in the HDAC2 in Complex with An Inhibitor
Mono view Stereo pair view
Sodium binding site 3 out of 3 in 7zzoGo back to Sodium Binding Sites List in 7zzo
Sodium binding site 3 out
of 3 in the HDAC2 in Complex with An Inhibitor
Mono view Stereo pair view
Reference:
E.Tamanini,
S.Miyamura,
I.M.Buck,
B.D.Cons,
L.Dawson,
C.East,
T.Futamura,
S.Goto,
C.Griffiths-Jones,
T.Hashimoto,
T.D.Heightman,
S.Ishikawa,
H.Ito,
Y.Kaneko,
T.Kawato,
K.Kondo,
N.Kurihara,
J.M.Mccarthy,
Y.Mori,
T.Nagase,
Y.Nakaishi,
J.Reeks,
A.Sato,
P.Schopf,
K.Tai,
T.Tamai,
D.Tisi,
A.J.Woolford.
Fragment-Based Discovery of A Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett. V. 13 1591 2022.
Page generated: Wed Oct 9 10:21:41 2024
ISSN: ISSN 1948-5875 PubMed: 36262388 DOI: 10.1021/ACSMEDCHEMLETT.2C00272 |
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