Sodium in PDB 7wyx: Cryo-Em Structure of Na+,K+-Atpase in the E2P State Formed By Atp with Istaroxime

The structure of Cryo-Em Structure of Na+,K+-Atpase in the E2P State Formed By Atp with Istaroxime also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Sodium atom in the Cryo-Em Structure of Na+,K+-Atpase in the E2P State Formed By Atp with Istaroxime (pdb code 7wyx). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Cryo-Em Structure of Na+,K+-Atpase in the E2P State Formed By Atp with Istaroxime, PDB code: 7wyx:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Cryo-Em Structure of Na+,K+-Atpase in the E2P State Formed By Atp with Istaroxime


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Cryo-Em Structure of Na+,K+-Atpase in the E2P State Formed By Atp with Istaroxime within 5.0Å range: probe atom residue distance (Å) B Occ A:Na1102 b:48.2 occ:1.00 OD2 A:ASP747 2.4 48.6 1.0 O A:ALA728 3.5 50.9 1.0 CG A:ASP747 3.6 48.6 1.0 O A:LYS726 3.7 60.5 1.0 O A:ASP729 3.9 48.6 1.0 O A:VAL279 4.2 77.6 1.0 OD1 A:ASP747 4.3 48.6 1.0 O A:LEU725 4.4 55.4 1.0 C A:ASP729 4.4 48.6 1.0 CB A:ASP747 4.6 48.6 1.0 C A:LYS726 4.7 60.5 1.0 C A:ALA728 4.7 50.9 1.0 CA A:ILE730 4.7 44.2 1.0 N A:ILE730 4.8 44.2 1.0 CG1 A:VAL279 4.9 77.6 1.0 N A:GLY731 5.0 44.6 1.0

Sodium binding site 2 out of 2 in the Cryo-Em Structure of Na+,K+-Atpase in the E2P State Formed By Atp with Istaroxime


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Cryo-Em Structure of Na+,K+-Atpase in the E2P State Formed By Atp with Istaroxime within 5.0Å range: probe atom residue distance (Å) B Occ C:Na1102 b:50.3 occ:1.00 OD2 C:ASP747 2.4 48.9 1.0 O C:ALA728 3.5 51.2 1.0 CG C:ASP747 3.6 48.9 1.0 O C:LYS726 3.7 60.7 1.0 O C:ASP729 3.9 48.7 1.0 O C:VAL279 4.2 78.5 1.0 OD1 C:ASP747 4.3 48.9 1.0 O C:LEU725 4.4 55.9 1.0 C C:ASP729 4.4 48.7 1.0 CB C:ASP747 4.6 48.9 1.0 C C:LYS726 4.7 60.7 1.0 C C:ALA728 4.7 51.2 1.0 CA C:ILE730 4.7 44.7 1.0 N C:ILE730 4.8 44.7 1.0 CG1 C:VAL279 4.9 78.5 1.0 N C:GLY731 5.0 45.5 1.0

R.Kanai, F.Cornelius, B.Vilsen, C.Toyoshima. Cryoelectron Microscopy of Na + ,K + -Atpase in the Two E2P States with and Without Cardiotonic Steroids. Proc.Natl.Acad.Sci.Usa V. 119 26119 2022.
ISSN: ESSN 1091-6490
PubMed: 35380894
DOI: 10.1073/PNAS.2123226119