Sodium in PDB 7sq7: Cryo-Em Structure of Mouse Pi(3,5)P2-Bound TRPML1 Channel at 2.41 Angstrom Resolution

The binding sites of Sodium atom in the Cryo-Em Structure of Mouse Pi(3,5)P2-Bound TRPML1 Channel at 2.41 Angstrom Resolution (pdb code 7sq7). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Cryo-Em Structure of Mouse Pi(3,5)P2-Bound TRPML1 Channel at 2.41 Angstrom Resolution, PDB code: 7sq7:

Sodium binding site 1 out of 1 in the Cryo-Em Structure of Mouse Pi(3,5)P2-Bound TRPML1 Channel at 2.41 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Cryo-Em Structure of Mouse Pi(3,5)P2-Bound TRPML1 Channel at 2.41 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Na602 b:30.0 occ:1.00 O D:GLY470 2.4 22.1 1.0 O A:GLY470 2.4 22.1 1.0 O C:GLY470 2.4 22.1 1.0 O B:GLY470 2.4 22.1 1.0 C D:GLY470 3.5 22.1 1.0 C A:GLY470 3.5 22.1 1.0 C C:GLY470 3.5 22.1 1.0 C B:GLY470 3.5 22.1 1.0 N D:ASP471 4.3 24.9 1.0 N A:ASP471 4.3 24.9 1.0 N C:ASP471 4.3 24.9 1.0 CA D:ASP471 4.3 24.9 1.0 CA A:ASP471 4.3 24.9 1.0 N B:ASP471 4.3 24.9 1.0 CA C:ASP471 4.4 24.9 1.0 CA B:ASP471 4.4 24.9 1.0 CA D:GLY470 4.4 22.1 1.0 CA A:GLY470 4.4 22.1 1.0 CA C:GLY470 4.4 22.1 1.0 CA B:GLY470 4.4 22.1 1.0 O D:ASN469 4.5 21.7 1.0 O A:ASN469 4.5 21.7 1.0 O B:ASN469 4.5 21.7 1.0 O C:ASN469 4.5 21.7 1.0 CB A:ASP471 4.7 24.9 1.0 CB D:ASP471 4.7 24.9 1.0 CB C:ASP471 4.7 24.9 1.0 CB B:ASP471 4.7 24.9 1.0 OD1 A:ASP471 4.8 24.9 1.0 OD1 D:ASP471 4.8 24.9 1.0 OD1 C:ASP471 4.8 24.9 1.0 OD1 B:ASP471 4.8 24.9 1.0

N.Gan, Y.Han, W.Zeng, Y.Wang, J.Xue, Y.Jiang. Structural Mechanism of Allosteric Activation of TRPML1 By Pi(3,5)P 2 and Rapamycin. Proc.Natl.Acad.Sci.Usa V. 119 2022.
ISSN: ESSN 1091-6490
PubMed: 35131932
DOI: 10.1073/PNAS.2120404119