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Atomistry » Sodium » PDB 7rhs-7s2a » 7s0u | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Sodium » PDB 7rhs-7s2a » 7s0u » |
Sodium in PDB 7s0u: PRMT5/MEP50 Crystal Structure with Mta and Phthalazinone Fragment BoundEnzymatic activity of PRMT5/MEP50 Crystal Structure with Mta and Phthalazinone Fragment Bound
All present enzymatic activity of PRMT5/MEP50 Crystal Structure with Mta and Phthalazinone Fragment Bound:
2.1.1.320; Protein crystallography data
The structure of PRMT5/MEP50 Crystal Structure with Mta and Phthalazinone Fragment Bound, PDB code: 7s0u
was solved by
R.J.Gunn,
N.C.Thomas,
J.D.Lawson,
A.Ivetac,
C.R.Smith,
S.Kulyk,
M.A.Marx,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7s0u:
The structure of PRMT5/MEP50 Crystal Structure with Mta and Phthalazinone Fragment Bound also contains other interesting chemical elements:
Sodium Binding Sites:
The binding sites of Sodium atom in the PRMT5/MEP50 Crystal Structure with Mta and Phthalazinone Fragment Bound
(pdb code 7s0u). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the PRMT5/MEP50 Crystal Structure with Mta and Phthalazinone Fragment Bound, PDB code: 7s0u: Sodium binding site 1 out of 1 in 7s0uGo back to![]() ![]()
Sodium binding site 1 out
of 1 in the PRMT5/MEP50 Crystal Structure with Mta and Phthalazinone Fragment Bound
![]() Mono view ![]() Stereo pair view
Reference:
C.R.Smith,
R.Aranda,
T.P.Bobinski,
D.M.Briere,
A.C.Burns,
J.G.Christensen,
J.Clarine,
L.D.Engstrom,
R.J.Gunn,
A.Ivetac,
R.Jean-Baptiste,
J.M.Ketcham,
M.Kobayashi,
J.Kuehler,
S.Kulyk,
J.D.Lawson,
K.Moya,
P.Olson,
L.Rahbaek,
N.C.Thomas,
X.Wang,
L.M.Waters,
M.A.Marx.
Fragment-Based Discovery of MRTX1719, A Synthetic Lethal Inhibitor of the PRMT5•Mta Complex For the Treatment of Mtap -Deleted Cancers. J.Med.Chem. V. 65 1749 2022.
Page generated: Fri Apr 7 16:09:58 2023
ISSN: ISSN 0022-2623 PubMed: 35041419 DOI: 10.1021/ACS.JMEDCHEM.1C01900 |
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