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Sodium in PDB 7rsv: Structure of the VPS34 Kinase Domain with Compound 5Enzymatic activity of Structure of the VPS34 Kinase Domain with Compound 5
All present enzymatic activity of Structure of the VPS34 Kinase Domain with Compound 5:
2.7.1.137; Protein crystallography data
The structure of Structure of the VPS34 Kinase Domain with Compound 5, PDB code: 7rsv
was solved by
D.X.Hu,
S.Patel,
H.Chen,
S.Wang,
S.Staben,
Y.N.Dimitrova,
H.A.Wallweber,
J.Y.Lee,
G.K.Y.Chan,
C.J.Sneeringer,
M.S.Prangley,
J.G.Moffat,
C.Wu,
L.K.Schutt,
L.Salphati,
J.Pang,
E.Mcnamara,
H.Huang,
Y.Chen,
Y.Wang,
W.Zhao,
J.Lim,
A.Murthy,
M.Siu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Sodium Binding Sites:
The binding sites of Sodium atom in the Structure of the VPS34 Kinase Domain with Compound 5
(pdb code 7rsv). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total 5 binding sites of Sodium where determined in the Structure of the VPS34 Kinase Domain with Compound 5, PDB code: 7rsv: Jump to Sodium binding site number: 1; 2; 3; 4; 5; Sodium binding site 1 out of 5 in 7rsvGo back to Sodium Binding Sites List in 7rsv
Sodium binding site 1 out
of 5 in the Structure of the VPS34 Kinase Domain with Compound 5
Mono view Stereo pair view
Sodium binding site 2 out of 5 in 7rsvGo back to Sodium Binding Sites List in 7rsv
Sodium binding site 2 out
of 5 in the Structure of the VPS34 Kinase Domain with Compound 5
Mono view Stereo pair view
Sodium binding site 3 out of 5 in 7rsvGo back to Sodium Binding Sites List in 7rsv
Sodium binding site 3 out
of 5 in the Structure of the VPS34 Kinase Domain with Compound 5
Mono view Stereo pair view
Sodium binding site 4 out of 5 in 7rsvGo back to Sodium Binding Sites List in 7rsv
Sodium binding site 4 out
of 5 in the Structure of the VPS34 Kinase Domain with Compound 5
Mono view Stereo pair view
Sodium binding site 5 out of 5 in 7rsvGo back to Sodium Binding Sites List in 7rsv
Sodium binding site 5 out
of 5 in the Structure of the VPS34 Kinase Domain with Compound 5
Mono view Stereo pair view
Reference:
D.X.Hu,
S.Patel,
H.Chen,
S.Wang,
S.T.Staben,
Y.N.Dimitrova,
H.A.Wallweber,
J.Y.Lee,
G.K.Y.Chan,
C.J.Sneeringer,
M.S.Prangley,
J.G.Moffat,
K.C.Wu,
L.K.Schutt,
L.Salphati,
J.Pang,
E.Mcnamara,
H.Huang,
Y.Chen,
Y.Wang,
W.Zhao,
J.Lim,
A.Murthy,
M.Siu.
Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors. J.Med.Chem. 2021.
Page generated: Thu Nov 25 10:32:23 2021
ISSN: ISSN 0022-2623 PubMed: 34779204 DOI: 10.1021/ACS.JMEDCHEM.1C01180 |
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