Sodium in PDB 7pwn: Urate Oxydase Aza-Xanthine Complex at 1000 Bars (100 Mpa) of Argon

All present enzymatic activity of Urate Oxydase Aza-Xanthine Complex at 1000 Bars (100 Mpa) of Argon:
1.7.3.3;

The structure of Urate Oxydase Aza-Xanthine Complex at 1000 Bars (100 Mpa) of Argon, PDB code: 7pwn was solved by T.Prange, N.Colloc'h, P.Carpentier, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.63 / 1.64
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	78.429, 95.177, 104.398, 90, 90, 90
R / Rfree (%)	17.6 / 20.9

The structure of Urate Oxydase Aza-Xanthine Complex at 1000 Bars (100 Mpa) of Argon also contains other interesting chemical elements:

Argon

(Ar)

4 atoms

The binding sites of Sodium atom in the Urate Oxydase Aza-Xanthine Complex at 1000 Bars (100 Mpa) of Argon (pdb code 7pwn). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Urate Oxydase Aza-Xanthine Complex at 1000 Bars (100 Mpa) of Argon, PDB code: 7pwn:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Urate Oxydase Aza-Xanthine Complex at 1000 Bars (100 Mpa) of Argon


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Urate Oxydase Aza-Xanthine Complex at 1000 Bars (100 Mpa) of Argon within 5.0Å range: probe atom residue distance (Å) B Occ A:Na1101 b:24.3 occ:1.00 O A:ILE88 2.1 22.8 1.0 O A:ILE94 2.2 21.5 1.0 O A:HOH1411 2.4 31.8 1.0 O A:TYR91 2.6 20.5 1.0 OE1 A:GLU136 2.7 32.1 1.0 C A:ILE88 3.2 21.6 1.0 O A:ASN92 3.2 35.3 1.0 C A:ILE94 3.4 18.8 1.0 CD A:GLU136 3.5 43.3 1.0 CA A:ILE88 3.6 21.4 1.0 C A:ASN92 3.6 28.0 1.0 C A:TYR91 3.6 24.6 1.0 OE2 A:GLU136 3.8 49.5 1.0 CA A:ASN92 3.8 30.7 1.0 N A:ILE94 4.0 20.5 1.0 CB A:ILE88 4.1 19.8 1.0 N A:ASN92 4.2 26.6 1.0 CA A:ILE94 4.2 18.7 1.0 O A:HOH1448 4.2 36.4 1.0 ND1 A:HIS95 4.3 34.8 1.0 N A:HIS95 4.3 18.3 1.0 N A:GLU89 4.4 23.0 1.0 N A:HIS93 4.4 25.3 1.0 CA A:HIS95 4.6 20.5 1.0 CB A:ILE94 4.7 18.2 1.0 O A:PHE87 4.7 20.5 1.0 CG A:GLU136 4.7 39.2 1.0 CA A:TYR91 4.8 22.2 1.0 C A:HIS93 4.8 21.4 1.0 N A:TYR91 4.9 21.5 1.0 CE1 A:HIS95 4.9 30.2 1.0 CG2 A:ILE88 4.9 23.4 1.0 N A:ILE88 4.9 19.8 1.0 CA A:GLU89 5.0 24.2 1.0

Sodium binding site 2 out of 2 in the Urate Oxydase Aza-Xanthine Complex at 1000 Bars (100 Mpa) of Argon


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Urate Oxydase Aza-Xanthine Complex at 1000 Bars (100 Mpa) of Argon within 5.0Å range: probe atom residue distance (Å) B Occ B:Na1101 b:18.9 occ:1.00 O B:ILE94 2.2 16.1 1.0 O B:ILE88 2.2 19.4 1.0 O B:HOH1420 2.4 25.1 1.0 O B:TYR91 2.6 16.1 1.0 OE1 B:GLU136 2.7 30.2 1.0 O B:ASN92 3.0 27.1 1.0 C B:ILE88 3.3 17.7 1.0 C B:ILE94 3.4 15.9 1.0 CD B:GLU136 3.5 35.7 1.0 C B:ASN92 3.5 23.9 1.0 C B:TYR91 3.6 20.3 1.0 CA B:ILE88 3.7 16.4 1.0 CA B:ASN92 3.8 24.6 1.0 OE2 B:GLU136 3.8 39.4 1.0 N B:ILE94 4.0 16.2 1.0 ND1 B:HIS95 4.1 28.7 1.0 N B:ASN92 4.1 21.9 1.0 CB B:ILE88 4.2 17.6 1.0 CA B:ILE94 4.2 15.2 1.0 O B:HOH1445 4.3 30.6 1.0 N B:HIS93 4.4 21.0 1.0 N B:HIS95 4.4 16.4 1.0 N B:GLU89 4.5 17.7 1.0 CE1 B:HIS95 4.6 27.5 1.0 CA B:HIS95 4.6 16.0 1.0 CG B:GLU136 4.7 30.7 1.0 CB B:ILE94 4.7 15.0 1.0 O B:PHE87 4.7 15.4 1.0 CA B:TYR91 4.8 18.4 1.0 C B:HIS93 4.8 17.0 1.0 N B:TYR91 4.9 18.0 1.0 CG2 B:ILE88 4.9 18.2 1.0 N B:ILE88 5.0 15.4 1.0 CA B:GLU89 5.0 18.7 1.0

T.Prange, P.Carpentier, A.C.Dhaussy, E.Girard, N.Colloc'h. Comparative Study of the Effects of High Hydrostatic Pressure Per Se and High Argon Pressure on Urate Oxidase Ligand Stabilization Acta Cryst. D V. 78 162 2022.
DOI: 10.1107/S2059798321012134