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Sodium in PDB 7o4g: Human Phosphomannomutase 2 (PMM2) Wild-Type Soaked with the Activator Glucose 1,6-Bisphosphate

Enzymatic activity of Human Phosphomannomutase 2 (PMM2) Wild-Type Soaked with the Activator Glucose 1,6-Bisphosphate

All present enzymatic activity of Human Phosphomannomutase 2 (PMM2) Wild-Type Soaked with the Activator Glucose 1,6-Bisphosphate:
5.4.2.8;

Protein crystallography data

The structure of Human Phosphomannomutase 2 (PMM2) Wild-Type Soaked with the Activator Glucose 1,6-Bisphosphate, PDB code: 7o4g was solved by S.Ramon-Maiques, A.Briso-Montiano, F.Del Cano-Ochoa, A.Vilas, B.Perez, V.Rubio, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 60.21 / 2.66
Space group P 65 2 2
Cell size a, b, c (Å), α, β, γ (°) 71.144, 71.144, 361.266, 90, 90, 120
R / Rfree (%) 22.4 / 27.3

Other elements in 7o4g:

The structure of Human Phosphomannomutase 2 (PMM2) Wild-Type Soaked with the Activator Glucose 1,6-Bisphosphate also contains other interesting chemical elements:

Chlorine (Cl) 1 atom
Magnesium (Mg) 4 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Human Phosphomannomutase 2 (PMM2) Wild-Type Soaked with the Activator Glucose 1,6-Bisphosphate (pdb code 7o4g). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Human Phosphomannomutase 2 (PMM2) Wild-Type Soaked with the Activator Glucose 1,6-Bisphosphate, PDB code: 7o4g:

Sodium binding site 1 out of 1 in 7o4g

Go back to Sodium Binding Sites List in 7o4g
Sodium binding site 1 out of 1 in the Human Phosphomannomutase 2 (PMM2) Wild-Type Soaked with the Activator Glucose 1,6-Bisphosphate


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Human Phosphomannomutase 2 (PMM2) Wild-Type Soaked with the Activator Glucose 1,6-Bisphosphate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na306

b:74.1
occ:1.00
 OD2 A:ASP48 3.4 70.3 1.0
OD1 A:ASP48 3.7 71.2 1.0
CG A:ASP48 3.7 58.2 1.0
OE1 A:GLU50 3.8 70.0 1.0
HB2 A:GLU50 4.3 49.3 1.0
HB3 A:ASP48 4.7 66.6 1.0
CB A:ASP48 4.8 54.5 1.0
CD A:GLU50 4.8 70.0 1.0
HB2 A:ASP48 4.9 66.6 1.0

Reference:

A.Briso-Montiano, F.Del Cano-Ochoa, A.Vilas, A.Velazquez-Campoy, V.Rubio, B.Perez, S.Ramon-Maiques. Insight on Molecular Pathogenesis and Pharmacochaperoning Potential in Phosphomannomutase 2 Deficiency, Provided By Novel Human Phosphomannomutase 2 Structures. J Inherit Metab Dis V. 45 318 2022.
ISSN: ISSN 1573-2665
PubMed: 34859900
DOI: 10.1002/JIMD.12461
Page generated: Tue Oct 8 18:17:09 2024

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