Sodium in PDB 7ku9: The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase with Sodium Ion at the Metal Coordination Site, Two Molecules of F6F Inhibitor at the Enzyme Alpha-Site and Another F6F Molecule at the Enzyme Beta-Site at 1.40 Angstrom Resolution

Enzymatic activity of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase with Sodium Ion at the Metal Coordination Site, Two Molecules of F6F Inhibitor at the Enzyme Alpha-Site and Another F6F Molecule at the Enzyme Beta-Site at 1.40 Angstrom Resolution

All present enzymatic activity of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase with Sodium Ion at the Metal Coordination Site, Two Molecules of F6F Inhibitor at the Enzyme Alpha-Site and Another F6F Molecule at the Enzyme Beta-Site at 1.40 Angstrom Resolution:
4.2.1.20;

Protein crystallography data

The structure of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase with Sodium Ion at the Metal Coordination Site, Two Molecules of F6F Inhibitor at the Enzyme Alpha-Site and Another F6F Molecule at the Enzyme Beta-Site at 1.40 Angstrom Resolution, PDB code: 7ku9 was solved by E.Hilario, M.F.Dunn, L.J.Mueller, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 36.79 / 1.40
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 183.259, 58.9, 67.23, 90, 94.82, 90
R / Rfree (%) 13.6 / 17.7

Other elements in 7ku9:

The structure of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase with Sodium Ion at the Metal Coordination Site, Two Molecules of F6F Inhibitor at the Enzyme Alpha-Site and Another F6F Molecule at the Enzyme Beta-Site at 1.40 Angstrom Resolution also contains other interesting chemical elements:

Chlorine (Cl) 3 atoms
Fluorine (F) 9 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase with Sodium Ion at the Metal Coordination Site, Two Molecules of F6F Inhibitor at the Enzyme Alpha-Site and Another F6F Molecule at the Enzyme Beta-Site at 1.40 Angstrom Resolution (pdb code 7ku9). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase with Sodium Ion at the Metal Coordination Site, Two Molecules of F6F Inhibitor at the Enzyme Alpha-Site and Another F6F Molecule at the Enzyme Beta-Site at 1.40 Angstrom Resolution, PDB code: 7ku9:

Sodium binding site 1 out of 1 in 7ku9

Go back to Sodium Binding Sites List in 7ku9
Sodium binding site 1 out of 1 in the The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase with Sodium Ion at the Metal Coordination Site, Two Molecules of F6F Inhibitor at the Enzyme Alpha-Site and Another F6F Molecule at the Enzyme Beta-Site at 1.40 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase with Sodium Ion at the Metal Coordination Site, Two Molecules of F6F Inhibitor at the Enzyme Alpha-Site and Another F6F Molecule at the Enzyme Beta-Site at 1.40 Angstrom Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Na1031

b:15.7
occ:1.00
 O B:GLY232 2.2 12.3 1.0
O B:HOH1235 2.2 22.5 1.0
O B:SER308 2.3 9.6 1.0
O B:HOH1323 2.4 14.3 1.0
O B:PHE306 2.5 14.0 1.0
C B:GLY232 3.4 10.1 1.0
C B:SER308 3.6 10.0 1.0
C B:PHE306 3.6 13.3 1.0
CG B:PRO270 3.8 11.0 1.0
CD B:PRO270 3.9 10.7 1.0
N B:SER308 4.0 12.2 1.0
CA B:GLY232 4.0 9.8 1.0
O B:GLY268 4.2 11.5 1.0
O B:LEU304 4.3 14.2 1.0
CB B:PHE306 4.3 13.9 1.0
CA B:SER308 4.4 11.3 1.0
CD2 B:PHE306 4.4 16.3 1.0
CA B:PHE306 4.4 14.3 1.0
O B:VAL231 4.4 9.6 1.0
OG B:SER297 4.5 16.8 1.0
N B:GLY233 4.5 10.1 1.0
N B:VAL309 4.5 10.2 1.0
C B:PRO307 4.6 14.7 1.0
N B:PHE306 4.6 14.6 1.0
N B:PRO307 4.6 13.5 1.0
CA B:VAL309 4.6 9.7 1.0
CB B:VAL309 4.7 10.8 1.0
CA B:PRO307 4.7 14.0 1.0
CG B:PHE306 4.8 15.9 1.0
CA B:GLY233 4.8 9.5 1.0
OE2 B:GLU256 4.8 11.3 1.0
N B:GLY232 5.0 10.0 1.0

Reference:

E.Hilario, M.F.Dunn, L.J.Mueller. The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase with Sodium Ion at the Metal Coordination Site, Two Molecules of F6F Inhibitor at the Enzyme Alpha-Site and Another F6F Molecule at the Enzyme Beta-Site at 1.40 Angstrom Resolution. To Be Published.
Page generated: Fri Dec 17 11:18:30 2021

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