Sodium in PDB 7evx: Crystal Structures of Na+,K+-Atpase in Complex with Istaroxime

Enzymatic activity of Crystal Structures of Na+,K+-Atpase in Complex with Istaroxime

All present enzymatic activity of Crystal Structures of Na+,K+-Atpase in Complex with Istaroxime:
7.2.2.13;

Protein crystallography data

The structure of Crystal Structures of Na+,K+-Atpase in Complex with Istaroxime, PDB code: 7evx was solved by H.Ogawa, F.Cornelius, R.Kanai, K.Motoyama, B.Vilsen, C.Toyoshima, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.98 / 3.71
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 115.109, 117.47, 491.339, 90, 90, 90
R / Rfree (%) 19.3 / 23.9

Other elements in 7evx:

The structure of Crystal Structures of Na+,K+-Atpase in Complex with Istaroxime also contains other interesting chemical elements:

Magnesium (Mg) 4 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structures of Na+,K+-Atpase in Complex with Istaroxime (pdb code 7evx). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Crystal Structures of Na+,K+-Atpase in Complex with Istaroxime, PDB code: 7evx:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in 7evx

Go back to Sodium Binding Sites List in 7evx
Sodium binding site 1 out of 2 in the Crystal Structures of Na+,K+-Atpase in Complex with Istaroxime


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structures of Na+,K+-Atpase in Complex with Istaroxime within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na1102

b:65.8
occ:1.00
OD2 A:ASP740 2.4 88.2 1.0
OD1 A:ASP740 2.9 88.2 1.0
CG A:ASP740 3.0 92.3 1.0
O A:LYS719 3.4 147.4 1.0
O A:GLY272 3.9 109.2 1.0
O A:ALA721 4.0 139.2 1.0
CA A:GLY272 4.2 124.0 1.0
C A:LYS719 4.3 138.3 1.0
O A:ALA738 4.5 93.3 1.0
CD A:LYS719 4.5 111.8 1.0
O A:SER718 4.5 118.6 1.0
CB A:ASP740 4.5 105.1 1.0
C A:GLY272 4.5 122.2 1.0
CA A:LYS719 4.6 129.3 1.0
O A:ASP722 4.8 97.1 1.0

Sodium binding site 2 out of 2 in 7evx

Go back to Sodium Binding Sites List in 7evx
Sodium binding site 2 out of 2 in the Crystal Structures of Na+,K+-Atpase in Complex with Istaroxime


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Crystal Structures of Na+,K+-Atpase in Complex with Istaroxime within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Na1102

b:39.7
occ:1.00
OD2 C:ASP740 2.4 78.2 1.0
OD1 C:ASP740 2.9 78.2 1.0
CG C:ASP740 3.0 81.4 1.0
O C:GLY272 3.4 124.4 1.0
O C:LYS719 3.6 166.1 1.0
O C:ALA721 3.7 145.3 1.0
O C:ASP722 4.3 117.3 1.0
C C:GLY272 4.3 132.7 1.0
CA C:GLY272 4.4 136.5 1.0
CB C:ASP740 4.5 91.2 1.0
O C:SER718 4.6 126.1 1.0
C C:LYS719 4.6 156.6 1.0
C C:ASP722 4.7 134.1 1.0
C C:ALA721 4.9 136.7 1.0
CA C:LYS719 5.0 152.3 1.0

Reference:

R.Kanai, F.Cornelius, H.Ogawa, K.Motoyama, B.Vilsen, C.Toyoshima. Binding of Cardiotonic Steroids to Na + ,K + -Atpase in the E2P State. Proc.Natl.Acad.Sci.Usa V. 118 2021.
ISSN: ESSN 1091-6490
PubMed: 33318128
DOI: 10.1073/PNAS.2020438118
Page generated: Mon Jul 12 15:56:58 2021

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